Search Result

Results for "

Fc domain

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) Apoptosis (1) CD3 (1) CTLA-4 (2) EGFR (2) FGFR (1) Insulin Receptor (1) Interleukin Related (2) PD-1/PD-L1 (2) STAT (1) TAM Receptor (1) TNF Receptor (1) VEGFR (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Inflammation/Immunology (5) Metabolic Disease (4)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Targets Recommended: Discoidin Domain Receptor Epigenetic Reader Domain WDR5 PIKfyve BCL6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99833

Cosibelimab CK-301; TG-1501	PD-1/PD-L1	Cancer
Cosibelimab (CK-301; TG-1501) is a high-affinity, fully human PD-L1-blocking monoclonal antibody that binds PD-L1 and blocks its interaction with PD-1. Cosibelimab has a functional Fc domain and is capable of inducing ADCC and complement-dependent cytotoxicity (CDC)-mediated killing of PD-L1 ⁺ cell lines, including lymphoma cells .

HY-P99930

Efruxifermin	FGFR	Metabolic Disease
Efruxifermin is an *Fc-FGF21* fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .

HY-P99487

Briobacept BR 3Fc	ADC Antibody	Inflammation/Immunology
Briobacept (BR 3FC) is a selective human monoclonal antibody targeting to BLyS (BAFF), induces B cells apoptosis. Briobacept is a recombinant glucoprotein, consists of 2 molecules from the BLyS receptor (BR3)and a Fc domain of human IgG1. Briobacept can be used in studies of rheumatoid arthritis (RA) .

HY-108829

Abatacept CTLA4lg; BMS-188667	CTLA-4	Inflammation/Immunology Cancer
Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains) . Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .

HY-P99562

Tidutamab XmAb-18087	CD3	Cancer
Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and *T-cell binding domain* (CD3)*. Tidutamab possesses a full Fc domain* to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC) .

HY-108829A

Abatacept (powder) CTLA4lg (powder); BMS-188667 (powder)	CTLA-4	Inflammation/Immunology Cancer
Abatacept (CTLA4lg; BMS-188667) powder is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept powder is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .

HY-P99030

Margetuximab	EGFR	Cancer
Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC₅₀ value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer .

HY-P99917

Eflepedocokin alfa	STAT	Inflammation/Immunology
Eflepedocokin alfa is a recombinant fusion protein with potential cell protective activity. Eflepedocokin alfa consists of human IL-22 fused to human *IgG2-Fc* domain. Eflepedocokin alfa leads to the activation of IL-22/IL-22R-mediated signal transduction pathways as well as STAT3. Eflepedocokin alfa plays a role in immune response and bacterial infection, enhancing intestinal barrier function, intestinal immunity, and tissue repair .

HY-108822

Rilonacept Arcalyst; IL 1 Trap; Interleukin 1 Trap	Interleukin Related	Inflammation/Immunology
Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes .

HY-P99115

Envafolimab ASC 22; KN 035	PD-1/PD-L1	Cancer
Envafolimab (ASC 22; KN 035) is a recombinant protein of a humanized single-domain anti- PD-L1 antibody. Envafolimab is created by a fusion of the of anti-PD-L1 domain with Fc fragment of human IgG1 antibody. Envafolimab blocks interaction between PD-L1 and PD-1 with an IC₅₀ value of 5.25 nM. Envafolimab has the potential for the research of solid tumors .

HY-P99470

Benufutamab GEN1029	TNF Receptor Apoptosis	Cancer
Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects .

HY-108801

Aflibercept VEGF Trap; VEGF-TRAPR1R2; VEGF-trapR1	VEGFR	Cardiovascular Disease Metabolic Disease
Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .

HY-108801A

Aflibercept (VEGF Trap)	VEGFR	Cardiovascular Disease Metabolic Disease
Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .

HY-P99665

Insulin efsitora alfa LY-3209590	Insulin Receptor	Metabolic Disease
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes .

HY-P99437

Anbenitamab KN-026	EGFR	Cancer
Anbenitamab (KN-026) is a bispecific antibody simultaneously targeting the extracellular domains II and IV of the human HER2. Anbenitamab blocks both ligand-dependent and ligand-independent HER2 signaling pathway. The IgG1 Fc fragment of Anbenitamab binds FcRγIIIa mediates potent antibody dependent cell-mediated cytotoxicity (ADCC) and inhibits tumor cell proliferation. Anbenitamab has the potential for HER2-positive metastatic breast cancer (MBC) research .

HY-P99463

Batiraxcept AVB-S6-500	TAM Receptor	Cancer
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-P99661

Inbakicept	Interleukin Related	Cancer
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells .

Cat. No.	Product Name	Target	Research Area

HY-P99833

Cosibelimab CK-301; TG-1501	PD-1/PD-L1	Cancer
Cosibelimab (CK-301; TG-1501) is a high-affinity, fully human PD-L1-blocking monoclonal antibody that binds PD-L1 and blocks its interaction with PD-1. Cosibelimab has a functional Fc domain and is capable of inducing ADCC and complement-dependent cytotoxicity (CDC)-mediated killing of PD-L1 ⁺ cell lines, including lymphoma cells .

HY-P99518

Taldefgrobep alfa BMS 986089; RG 6206; RO 7239361	Inhibitory Antibodies	Others
Taldefgrobep alfa (BMS 986089; RG 6206; RO 7239361) is a potent inhibitory antibody targeting to human myostatin. Taldefgrobep alfa is a fusion protein composed of a human IgG1-Fc domain and Adnectin domain. Taldefgrobep alfa can be used for spinal muscular atrophy (SMA) research .

HY-P99930

Efruxifermin	FGFR	Metabolic Disease
Efruxifermin is an *Fc-FGF21* fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .

HY-P99487

Briobacept BR 3Fc	ADC Antibody	Inflammation/Immunology
Briobacept (BR 3FC) is a selective human monoclonal antibody targeting to BLyS (BAFF), induces B cells apoptosis. Briobacept is a recombinant glucoprotein, consists of 2 molecules from the BLyS receptor (BR3)and a Fc domain of human IgG1. Briobacept can be used in studies of rheumatoid arthritis (RA) .

HY-P99562

Tidutamab XmAb-18087	CD3	Cancer
Tidutamab (XmAb-18087) is a humanized and affinity-optimized bispecific antibody (bsAb) targeting SSTR2 binding domain and *T-cell binding domain* (CD3)*. Tidutamab possesses a full Fc domain* to maintain long serum half-life.Tidutamab eliminates SSTR+ tumor cells by stimulating redirected T cellmediated cytotoxicity (RTcC) .

HY-108829

Abatacept CTLA4lg; BMS-188667	CTLA-4	Inflammation/Immunology Cancer
Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains) . Abatacept is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .

HY-108829A

Abatacept (powder) CTLA4lg (powder); BMS-188667 (powder)	CTLA-4	Inflammation/Immunology Cancer
Abatacept (CTLA4lg; BMS-188667) powder is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). Abatacept powder is a selective T-cell co-stimulation modulator and a protein agent for the autoimmune diseases .

HY-P99030

Margetuximab	EGFR	Cancer
Margetuximab (MGAH22) is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC₅₀ value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer .

HY-P99917

Eflepedocokin alfa	STAT	Inflammation/Immunology
Eflepedocokin alfa is a recombinant fusion protein with potential cell protective activity. Eflepedocokin alfa consists of human IL-22 fused to human *IgG2-Fc* domain. Eflepedocokin alfa leads to the activation of IL-22/IL-22R-mediated signal transduction pathways as well as STAT3. Eflepedocokin alfa plays a role in immune response and bacterial infection, enhancing intestinal barrier function, intestinal immunity, and tissue repair .

HY-108822

Rilonacept Arcalyst; IL 1 Trap; Interleukin 1 Trap	Interleukin Related	Inflammation/Immunology
Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes .

HY-P99115

Envafolimab ASC 22; KN 035	PD-1/PD-L1	Cancer
Envafolimab (ASC 22; KN 035) is a recombinant protein of a humanized single-domain anti- PD-L1 antibody. Envafolimab is created by a fusion of the of anti-PD-L1 domain with Fc fragment of human IgG1 antibody. Envafolimab blocks interaction between PD-L1 and PD-1 with an IC₅₀ value of 5.25 nM. Envafolimab has the potential for the research of solid tumors .

HY-P99470

Benufutamab GEN1029	TNF Receptor Apoptosis	Cancer
Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects .

HY-108801

Aflibercept VEGF Trap; VEGF-TRAPR1R2; VEGF-trapR1	VEGFR	Cardiovascular Disease Metabolic Disease
Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .

HY-108801A

Aflibercept (VEGF Trap)	VEGFR	Cardiovascular Disease Metabolic Disease
Aflibercept (VEGF Trap) is a soluble decoy VEGFR constructed by fusing the Ig domains of VEGFR1 and VEGFR2 with the Fc region of human IgG1. Aflibercept inhibits VEGF signaling by reducing VEGF-regulated processes. Aflibercept can be used for thr research of age-related macular degeneration (AMD) and cardiovascular disease .

HY-P99665

Insulin efsitora alfa LY-3209590	Insulin Receptor	Metabolic Disease
Insulin efsitora alfa (LY-3209590) is a selective agonist of insulin receptor (IR). Insulin efsitora alfa is a fusion protein composed of human IR agonists fused with the crystallizable (Fc) domain of human immunoglobulin G2 (IgG2) fragment, with a molecular weight of 64.1 kDa. Insulin efsitora alfa is well tolerated and has potential applications in diabetes .

HY-P99777

Ontorpacept TTI-621	Inhibitory Antibodies	Cancer
Ontorpacept (TTI-621) is a soluble fusion protein that consists of the human SIRPα N-terminal (1-118) linked to the Fc region of human IgG1. The N-terminal (1-118)-fragment of ontorpacept is a binding domain for CD47 which is an inhibitor of phagocytosis by macrophages. Ontorpacept is a CD47-blocking checkpoint inhibitor with antitumor activity .

HY-P99437

Anbenitamab KN-026	EGFR	Cancer
Anbenitamab (KN-026) is a bispecific antibody simultaneously targeting the extracellular domains II and IV of the human HER2. Anbenitamab blocks both ligand-dependent and ligand-independent HER2 signaling pathway. The IgG1 Fc fragment of Anbenitamab binds FcRγIIIa mediates potent antibody dependent cell-mediated cytotoxicity (ADCC) and inhibits tumor cell proliferation. Anbenitamab has the potential for HER2-positive metastatic breast cancer (MBC) research .

HY-P99463

Batiraxcept AVB-S6-500	TAM Receptor	Cancer
Batiraxcept (AVB-S6-500) is a highly potent and specific AXL inhibitor, a recombinant fusion protein dimer containing the extracellular domain of human AXLM and human immunoglobulin G1 heavy chain (Fc). Batiraxcept binds to GAS6 and inhibits the interaction of GAS6 with AXL, thereby substantially reducing AXL signaled invasion and migration of highly metastatic cells in vitro and inhibiting metastatic disease in nonclinical models of aggressive human cancers. Batiraxcept is available for studies in advanced or metastatic clear cell renal cell carcinoma (ccRCC) and platinum sensitive recurrent ovarian cancer .

HY-P99661

Inbakicept	Interleukin Related	Cancer
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells .

Species:	Human (30) Virus (2) Rhesus Macaque (6) Mouse (14) Rat (5) Cynomolgus (2) Canine (1)
Tag:	His (3) Avi (4) Fc (60)
Source:	HEK293 (60)

Cat. No.	Compare	Product Name	Species	Source

HY-P77217

	SUSD4 Protein, Human (HEK293, Fc) Sushi domain-containing protein 4	Human	HEK293
	SUSD4 protein acts as a complement inhibitor by disrupting classical C3 convertase formation. Isoform 3 specifically inhibits the classical complement pathway, and membrane-bound isoform 1 inhibits C3b deposition through classical and alternative pathways, showcasing SUSD4's regulatory role in complement activation and potential significance in immune response modulation. SUSD4 Protein, Human (HEK293, Fc) is the recombinant human-derived SUSD4 protein, expressed by HEK293, with C-mFc labeled tag. The total length of SUSD4 Protein, Human (HEK293, Fc) is 249 a.a., with molecular weight of ~67 kDa.

HY-P7496

	AMIGO2 Protein, Human (HEK293, Fc) rHuAmphoterin-Induced Protein 2, C-Fc; AMIGO2; Alivin-1; Adhesion Molecule with Ig-like domain 2; Amphoterin-Induced Protein 2	Human	HEK293
	AMIGO2 Protein, Human (HEK293, Fc) 3 is a single-pass type I membrane cell adhesion protein, which belongs to the family of leucinerich repeat (LRR) containing proteins..

HY-P77248

	TMIGD1 Protein, Human (HEK293, Fc) Transmembrane and immunoglobulin domain-containing protein 1; TMIGD	Human	HEK293
	TMIGD1 is a potential regulator that affects multiple cellular processes, including adhesion, migration, proliferation, and morphology. Its protective effect against oxidative damage in renal epithelial cells promotes cell survival. TMIGD1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMIGD1 Protein, Human (HEK293, Fc) is 220 a.a., with molecular weight of ~47.5 KDa.

HY-P74460

	Zika virus E/Envelope Protein (107a.a, HEK293, Fc) Zika virus (ZIKV) (strain Zika SPH2015) ZIKV-E/Envelope protein (domain III, Fc)	Virus	HEK293
	Genome polyprotein is a smaller protein chain of covalent linkages that is a key component of virus survival and replication. Zika virus E/Envelope Protein (107a.a, HEK293, Fc) is the recombinant Virus-derived Zika virus E/Envelope protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Zika virus E/Envelope Protein (107a.a, HEK293, Fc) is 107 a.a., with molecular weight of ~38.2 kDa.

HY-P75665

	CDCP1 Protein, Mouse (HEK293, Fc) CUB domain-containing protein 1; SIMA135; CD318; TRASK	Mouse	HEK293
	The CDCP1 protein has been implicated in cell adhesion and matrix association, suggesting a role in important cellular interactions. Its phosphorylation suggests a dynamic function in regulating anchorage, migration, proliferation, or differentiation. CDCP1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CDCP1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CDCP1 Protein, Mouse (HEK293, Fc) is 666 a.a., with molecular weight of ~117 kDa.

HY-P76288

	CRELD2 Protein, Mouse (HEK293, Fc) Cysteine-Rich With EGF-Like domain Protein 2; CRELD2	Mouse	HEK293
	CRELD2 Protein, potentially acting as a protein disulfide isomerase, may play a role in the unfolded protein response. It is also implicated in regulating the transport of the alpha4-beta2 neuronal acetylcholine receptor, showcasing its versatility in cellular processes related to protein folding and neuronal receptor dynamics. These functions suggest CRELD2's involvement in maintaining cellular homeostasis. CRELD2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CRELD2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CRELD2 Protein, Mouse (HEK293, Fc) is 350 a.a., with molecular weight of ~62.8 KDa.

HY-P74457

	Zika virus E/Envelope Protein (97a.a, HEK293, Fc) Zika virus (ZIKV) (strain Zika SPH2016) ZIKV-E (Stem/anchor domain of flavivirus envelope glycoprotein E) protein (Fc)	Virus	HEK293
	Genome polyprotein is a smaller protein chain of covalent linkages that is a key component of virus survival and replication. Zika virus E/Envelope Protein (97a.a, HEK293, Fc) is the recombinant Virus-derived Zika virus E/Envelope protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Zika virus E/Envelope Protein (97a.a, HEK293, Fc) is 97 a.a., with molecular weight of ~36.7 kDa.

HY-P77057

	LDLRAD3 Protein, Human (HEK293, Fc) Low-density lipoprotein receptor class A domain-containing protein 3; LRAD3	Human	HEK293
	LDLRAD3 protein significantly affects the processing of amyloid precursor protein (APP), possibly reducing soluble APP-α (sAPP-α) and increasing the production of amyloid P3 peptide. Suggested regulation of ITCH and NEDD4 E3 ligases. LDLRAD3 Protein, Human (HEK293, Fc) is the recombinant human-derived LDLRAD3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of LDLRAD3 Protein, Human (HEK293, Fc) is 156 a.a., with molecular weight of ~43.8 KDa.

HY-P75803

	HE4/WFDC2 Protein, Canine (HEK293, Fc) WAP four-disulfide core domain protein 2; CE4; WFDC2	Canine	HEK293
	HE4/WFDC2 protein acts as a broad-spectrum protease inhibitor and may affect a variety of cellular processes. Its effect on sperm maturation suggests its role in reproductive mechanisms. HE4/WFDC2 Protein, Canine (HEK293, Fc) is the recombinant canine-derived HE4/WFDC2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of HE4/WFDC2 Protein, Canine (HEK293, Fc) is 97 a.a., with molecular weight of ~43-50 kDa.

HY-P76270

	CLEC9A Protein, Mouse (HEK293, Fc) C-type lectin domain family 9 member A; CD370; Dngr-1	Mouse	HEK293
	The CLEC9A protein is uniquely expressed on specific myeloid cells and acts as an endocytic receptor responsible for the uptake and processing of materials from dead cells. CLEC9A recognizes filamentous actin, especially in damaged cell membranes, and plays a critical role in Syk-dependent cross-presentation of dead cell antigens. CLEC9A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC9A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC9A Protein, Mouse (HEK293, Fc) is 208 a.a., with molecular weight of ~52.1 KDa.

HY-P77336

	CLEC4E Protein, Rhesus Macaque (HEK293, Fc) C-Type Lectin domain Family 4 Member E; CLECSF9; MINCLE	Rhesus Macaque	HEK293
	CLEC4E Protein is a calcium-dependent lectin displaying mannose-binding specificity, and induces the formation of Birbeck granules (BGs). CLEC4E Protein is a potent regulator of membrane superimposition and zippering, and binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. CLEC4E Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC4E protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC4E Protein, Rhesus Macaque (HEK293, Fc) is 179 a.a., with molecular weight of ~49.1 KDa.

HY-P77437

	Langerin/CD207 Protein, Rhesus Macaque (HEK293, Fc) C-type lectin domain family 4 member K; CLEC4K	Rhesus Macaque	HEK293
	Langerin, also known as CD207, is a calcium-dependent lectin with mannose-binding specificity. Notably, it induces the formation of Birbeck granules (BG) and acts as an effective regulator of membrane stacking and zipping. Langerin/CD207 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Langerin/CD207 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Langerin/CD207 Protein, Rhesus Macaque (HEK293, Fc) is 264 a.a., with molecular weight of ~58.3 KDa.

HY-P71425

	VSIG8 Protein, Human (HEK293, Fc) V-set and immunoglobulin domain-containing protein 8; VSIG8; C1orf204	Human	HEK293
	V-set and immunoglobulin domain-containing protein 8 (VSIG8) is a membrane protein belonging to complement receptor of the immunoglobulin superfamily. VSIG8 has RNA binding activity and is a human T-cell co-inhibitory ligand. VSIG-8 inhibits the production of cytokines, chemokines and other proteins on T cells, and also suppresses T cell proliferation and differentiation of na茂ve T cells. VSIG8 Protein, Human (HEK293, Fc) is the recombinant human-derived VSIG8 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VSIG8 Protein, Human (HEK293, Fc) is 242 a.a., with molecular weight of ~57.0 kDa.

HY-P75303

	DDR1 Protein, Mouse (HEK293, Fc) Epithelial discoidin domain-containing receptor 1; HGK2; CD167a; CAK; EDDR1	Mouse	HEK293
	DDR1 Protein, a fibrillar collagen receptor, orchestrates critical cellular processes, including matrix remodeling, migration, differentiation, survival, and proliferation. Upon collagen binding, DDR1 activates a signaling cascade involving SRC and MAP kinases, contributing to matrix remodeling through MMP up-regulation, facilitating cell migration, wound healing, and tumor invasion. DDR1 also aids arterial wound healing, phosphorylates PTPN11, and is vital for blastocyst implantation, mammary gland differentiation, lactation, and ear morphology maintenance. Its multifunctional role underscores DDR1's significance in governing diverse physiological processes. DDR1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived DDR1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of DDR1 Protein, Mouse (HEK293, Fc) is 414 a.a., with molecular weight of 80-90 kDa.

HY-P76286

	CRELD1 Protein, Mouse (HEK293, Fc) Protein disulfide isomerase CRELD1; Cysteine-rich with EGF-like domain protein 1; CIRRIN	Mouse	HEK293
	The CRELD1 protein is a member of the protein disulfide isomerase family and is actively involved in rearrangements of disulfide bonds that contribute to important cellular processes. Of particular note is the role of CRELD1 in promoting the localization of acetylcholine receptors (AChR) to the plasma membrane. CRELD1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CRELD1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CRELD1 Protein, Mouse (HEK293, Fc) is 362 a.a., with molecular weight of ~63 KDa.

HY-P76830

CLEC2B Protein, Human (HEK293, Fc)

C-type lectin domain family 2 member B; AICL; CLECSF2; IFNRG1
Human HEK293

HY-P77238

	TM2D1 Protein, Human (HEK293, Fc) TM2 domain-containing protein 1; Amyloid-beta-binding protein; hBBP; BBP	Human	HEK293
	The TM2D1 protein may be involved in amyloid beta-induced apoptosis by interacting with beta-APP42, especially amyloid beta protein 42 (APP beta-APP42). This suggests a role in molecular pathways associated with amyloid-induced cell death. TM2D1 Protein, Human (HEK293, Fc) is the recombinant human-derived TM2D1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TM2D1 Protein, Human (HEK293, Fc) is 81 a.a., with molecular weight of 45-60 KDa.

HY-P77368

	Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc) Collagen/fibrinogen domain-containing protein 1; Ficolin-A; M-ficolin; FcN1; FcNM	Rhesus Macaque	HEK293
	Ficolin-1 functions locally after inflammatory lesions in monocyte, macrophage, and granulocyte secretion, and is also present in serum, suggesting that it may play a role in systemic immunity. Ficolins recognize and bind to pathogens, leading to neutralization and conditioning, which subsequently activates the complement lectin pathway. Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Ficolin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Ficolin-1 Protein, Rhesus Macaque (HEK293, Fc) is 297 a.a., with molecular weight of ~59.1 KDa.

HY-P76829

CLEC14A Protein, Rat (HEK293, Fc)

C-type lectin domain family 14 member A; EGFR-5; C14orf27
Rat HEK293

HY-P76868

	DDR2 Protein, Human (HEK293, Fc) Discoidin domain-containing receptor 2; CD167b; Ddr2; Ntrkr3; Tkt; Tyro10	Human	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Human (HEK293, Fc) is the recombinant human-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR2 Protein, Human (HEK293, Fc) is 399 a.a., with molecular weight of ~87 kDa.

HY-P7839

	BCMA/TNFRSF17 Protein, Cynomolgus (HEK293, Fc) rCynBCMA-Tall_bind domain-containing protein/BCMA, Fc; Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17; Bcm; Bcma	Cynomolgus	HEK293
	B Cell Maturation Antigen (BCMA) also referred to as TNFRSF17 or CD269, is a transmembrane glycoprotein member of the tumor necrosis factor receptor (TNFR) superfamily. BCMA is used as a biomarker for Multiple myeloma (MM). BCMA mainly plays an important role in B cells for their proliferation, survival and also differentiates them into plasma cells. BCMA/TNFRSF17 Protein, Cynomolgus (HEK293, Fc) is a recombinant protein with a C-Terminal Fc label, It consists of 53 amino acids (M1-A53) and is produced in HEK293 cells.

HY-P7835

	ILDR2/B7-2 Protein, Cynomolgus (HEK293, Fc) rCynIg-like domain-containing protein/B7-2, Fc; T-lymphocyte activation antigen CD86 isoform 1; Activation B7-2 antigen; CD86	Cynomolgus	HEK293
	The Ig-like domain of Ig-like domain-containing protein is a classic structure of tailed double-stranded (ds) DNA phage particles, which may be formed through weak interactions with carbohydrates on the surface of bacterial cells. Play an auxiliary role in phage infection. ILDR2/B7-2 Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived ILDR2/B7-2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ILDR2/B7-2 Protein, Cynomolgus (HEK293, Fc) is 222 a.a., with molecular weight of 90-120 kDa.

HY-P75335

	CLEC1B/CLEC-2 Protein, Mouse (HEK293, Fc) C-type lectin domain family 1 member B; CLEC1B; CLEC2	Mouse	HEK293
	The CLEC1B/CLEC-2 protein serves as a platelet receptor for PDPN. When activated, it signals through SRC and SYK kinases, activating PLCG2. CLEC1B forms homodimers and interacts with RACK1, promoting its ubiquitination and degradation. It also interacts with SYK and PDPN, independently of glycosylation, activating CLEC1B/CLEC-2. CLEC1B/CLEC-2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC1B/CLEC-2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC1B/CLEC-2 Protein, Mouse (HEK293, Fc) is 177 a.a., with molecular weight of 50-65 kDa.

HY-P75337

	CLEC-1/CLEC1A Protein, Rat (HEK293, Fc) CLEC1A; C-type lectin domain family 1 member A; CLEC1	Rat	HEK293
	CLEC-1/CLEC1A proteins belong to the CTL/CTLD superfamily and are known for their diverse functions in cell adhesion, signaling, glycoprotein turnover, inflammation, and immune responses. It is involved in potentially regulating dendritic cell function. CLEC-1/CLEC1A Protein, Rat (HEK293, Fc) is the recombinant rat-derived CLEC-1/CLEC1A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC-1/CLEC1A Protein, Rat (HEK293, Fc) is 197 a.a., with molecular weight of ~51.6 kDa.

HY-P75338

	CLEC-1/CLEC1A Protein, Human (HEK293, Fc) CLEC1A; C-type lectin domain family 1 member A; CLEC1	Human	HEK293
	CLEC-1/CLEC1A proteins belong to the CTL/CTLD superfamily and are known for their diverse functions in cell adhesion, signaling, glycoprotein turnover, inflammation, and immune responses. It is involved in potentially regulating dendritic cell function. CLEC-1/CLEC1A Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC-1/CLEC1A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC-1/CLEC1A Protein, Human (HEK293, Fc) is 204 a.a., with molecular weight of ~56.48 kDa.

HY-P75702

	DDR2 Protein, Rhesus Macaque (HEK293, Fc) Discoidin domain-containing receptor 2; CD167b; Ddr2; Ntrkr3; Tkt; Tyro10	Rhesus Macaque	HEK293
	The DDR2 protein is a tyrosine kinase critical in tissue remodeling, acting as a cell surface receptor for fibrillar collagen and affecting cell differentiation, extracellular matrix remodeling, migration, and proliferation. DDR2 is critical for bone development and centrally regulates osteoblast differentiation and chondrocyte maturation through MAP kinase signaling and activation of RUNX2. DDR2 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived DDR2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of DDR2 Protein, Rhesus Macaque (HEK293, Fc) is 399 a.a., with molecular weight of ~69.7 kDa.

HY-P77243

	TMED4 Protein, Human (HEK293, Fc) Transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMED4 Protein, Human (HEK293, Fc) is 194 a.a., with molecular weight of ~45.6 KDa.

HY-P77338

	CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) C-type lectin domain family 5 member A; MDL-1; CLECSF5	Rhesus Macaque	HEK293
	CLEC5A Protein is a cell surface receptor that signals via TYROBP, and functions as a positive regulator of osteoclastogenesis. CLEC5A Protein regulates inflammatory responses. CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CLEC5A/MDL-1 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of CLEC5A/MDL-1 Protein, Rhesus Macaque (HEK293, Fc) is 161 a.a., with molecular weight of ~45.3 KDa.

HY-P76699

	VSIG4 Protein, Mouse (HEK293, His-Fc) V-set and immunoglobulin domain-containing protein 4; Protein Z39Ig; Z39IG; CRIg	Mouse	HEK293
	V-set and immunoglobulin domain containing 4 (Vsig4) is a membrane protein belonging to complement receptor of the immunoglobulin superfamily. Vsig4 may be a negative regulator of T-cell responses and interleukin-2 production, Vsig4 also mediates clearance of C3b opsonized pathogens by binding C3b. The expression of VSIG4 is restricted to tissue macrophages where Vsig4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism. VSIG4 Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived VSIG4 protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of VSIG4 Protein, Mouse (HEK293, His-Fc) is 187 a.a., with molecular weight of ~60 kDa.

HY-P76835

	CLEC4D Protein, Rat (HEK293, Fc) C-type lectin domain family 4 member D; CLEC-6; Dectin-3; CD368; CLECSF8	Rat	HEK293
	CLEC4D, a calcium-dependent lectin, detects DAMPs and PAMPs from bacteria and fungi. It interacts with FCER1G in myeloid cells, forming a functional complex that activates signaling pathways and promotes antigen-presenting cell maturation and T-cell priming. CLEC4D also combats fungal infections and contributes to antigen uptake for clearance or presentation to T-cells. Its interaction with CLEC4E strengthens the interaction with FCER1G. CLEC4D Protein, Rat (HEK293, Fc) is the recombinant rat-derived CLEC4D protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC4D Protein, Rat (HEK293, Fc) is 171 a.a., with molecular weight of ~53 kDa.

HY-P71423

	VSIG4 Protein, Human (HEK293, Fc) V-set and immunoglobulin domain-containing protein 4; VSIG4; Protein Z39Ig; Z39IG; CRIg	Human	HEK293
	VSIG4 Protein, a phagocytic receptor, robustly inhibits T-cell proliferation and IL2 production, serving as a potent alternative complement pathway convertase inhibitor. VSIG4 Protein, Human (HEK293, Fc) is the recombinant human-derived VSIG4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of VSIG4 Protein, Human (HEK293, Fc) is 265 a.a., with molecular weight of ~75.0 kDa.

HY-P76684

	TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) TR-1; H7365; Transmembrane protein with EGF-like and one follistatin-like domain; C9orf2	Human	HEK293
	TMEFF1/Tomoregulin-1 protein may inhibit NODAL and BMP signaling in neural patterning, suggesting a regulatory role in neural development. It has been proposed as a tumor suppressor in brain cancer, emphasizing its importance in mitigating abnormal cell growth. TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is 291 a.a., with molecular weight of ~65 kDa.

HY-P76935

	FNDC4 Protein, Human (HEK293, Fc) Fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1; FRCP1	Human	HEK293
	The FNDC4 protein is an anti-inflammatory factor in the intestine and colon that regulates macrophages by downregulating pro-inflammatory gene expression and affecting phagocytosis. It does this by modulating key pathways associated with macrophage activation, in part through STAT3 activation and signaling. FNDC4 Protein, Human (HEK293, Fc) is the recombinant human-derived FNDC4 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of FNDC4 Protein, Human (HEK293, Fc) is 123 a.a., with molecular weight of ~50-60 KDa.

HY-P77252

	TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) TR-1; H7365; Transmembrane protein with EGF-like and one follistatin-like domain; C9orf2	Mouse	HEK293
	TMEFF1/Tomoregulin-1 Protein is a transmembrane protein involved in the physiological functions of the central nervous system, embryonic development, and other biological processes. TMEFF1 may inhibit NODAL and BMP signaling during neural patterning. And it may be a tumor suppressor in brain cancers. Additionally, the protein may interact with ST14, implying a molecular association that may contribute to its regulatory and signaling functions. TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is 298 a.a., with molecular weight of ~69 kDa.

HY-P77282

	VSTM1 Protein, Human (HEK293, Fc) V-set and transmembrane domain-containing protein 1; SIRL-1; Signal inhibitory receptor on leukocytes-1; VSTM1	Human	HEK293
	VSTM1 interacts with S100A10 protein, inducing the dimerization of ANXA2/p36. This suggests a regulatory role in protein phosphorylation, with ANXA2 monomer being the preferred target for tyrosine-specific kinase in vitro. The resulting heterotetramer comprises two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. Furthermore, VSTM1 engages with SCN10A and TASOR, indicating its participation in diverse molecular interactions. VSTM1 Protein, Human (HEK293, Fc) is the recombinant human-derived VSTM1 protein, expressed by HEK293, with C-hFc labeled tag. The total length of VSTM1 Protein, Human (HEK293, Fc) is 135 a.a., with molecular weight of 50-60 kDa.

HY-P7641

	B7-H4 Protein, Mouse (HEK293, Fc) rMuB7-H4, C-Fc; V-set domain containing T-cell activation inhibitor 1; B7 homolog 4; Protein B7S1; B7-H4;	Mouse	HEK293
	B7-H4 Protein, Mouse (HEK293, Fc) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells.

HY-P75637

	CD302/CLEC13A Protein, Mouse (HEK293, Fc) CD302 antigen; C-type lectin domain family 13 member A; CD302; CLEC13A	Mouse	HEK293
	CD302/CLEC13A Protein, a potential multifunctional C-type lectin receptor, may engage in endocytosis, phagocytosis, cell adhesion, and migration processes. CD302/CLEC13A Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD302/CLEC13A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD302/CLEC13A Protein, Mouse (HEK293, Fc) is 136 a.a., with molecular weight of ~48 kDa.

HY-P76679

	TMED9 Protein, Human (HEK293, Fc) Transmembrane emp24 domain-containing protein 9; GMP25; p24alpha2; p25; GP25L2	Human	HEK293
	TMED9, a key player in vesicular protein trafficking, operates prominently in the early secretory pathway, specifically in COPI vesicle-mediated retrograde transport. It facilitates coatomer recruitment to membranes, enhances ARFGAP2 activity, and ensures specific retention of p24 complexes in cis-Golgi membranes, notably influencing TMED2 and TMED10 localization. Beyond retrograde transport, TMED9 contributes to intracellular membrane organization, including the ER-Golgi intermediate compartment and Golgi apparatus, and participates in PTPN2 isoform PTPB ER localization. TMED9's dynamic oligomeric states involve monomers and homodimers, influenced by its interactions with EMP24/GP25L family members (TMED2, TMED7, and TMED10) and specific associations with TMED5, COPG1, PTPN2, SPAST, and STX17. TMED9 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED9 protein, expressed by HEK293, with C-mFc labeled tag. The total length of TMED9 Protein, Human (HEK293, Fc) is 202 a.a., with molecular weight of ~45.8 kDa.

HY-P76795

	CD302/CLEC13A Protein, Rat (HEK293, Fc) CD302 antigen; C-type lectin domain family 13 member A; CD302; CLEC13A	Rat	HEK293
	The CD302/CLEC13A protein emerged as a potential multifunctional C-type lectin receptor, indicating its widespread involvement in cellular processes. This protein has a potential role in endocytosis and phagocytosis and is involved in cellular clearance. CD302/CLEC13A Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD302/CLEC13A protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD302/CLEC13A Protein, Rat (HEK293, Fc) is 165 a.a., with molecular weight of ~47 kDa.

HY-P76831

	OCIL/CLEC2D Protein, Rat (HEK293, Fc) C-type lectin domain family 2 member D5; Osteoclast inhibitory lectin; Ocil; Clec2d5	Rat	HEK293
	The OCIL/CLEC2D protein, also known as osteoclast inhibitory lectin (OCIL) or C-type lectin domain family 2 member D (CLEC2D), functions as a lectin-type receptor located on the cell surface. Lectins are proteins that specifically bind to carbohydrates, and OCIL/CLEC2D is involved in carbohydrate recognition and signaling processes by acting as a lectin-type receptor. OCIL/CLEC2D Protein, Rat (HEK293, Fc) is the recombinant rat-derived OCIL/CLEC2D protein, expressed by HEK293 , with N-hFc labeled tag. The total length of OCIL/CLEC2D Protein, Rat (HEK293, Fc) is 136 a.a., with molecular weight of 44-54 & 36 kDa, respectively.

HY-P77249

	TMIGD2 Protein, Human (HEK293, Fc) Transmembrane and immunoglobulin domain-containing protein 2; Immunoglobulin and proline-rich receptor 1; IGPR1; TMIGD2	Human	HEK293
	TMIGD2, a multifaceted protein, actively participates in cellular processes, including cell-cell interaction, migration, and angiogenesis. Its interaction with HHLA2 enhances T-cell proliferation and cytokine production through AKT-dependent signaling during TCR-mediated activation. TMIGD2 may engage in homophilic interactions, regulating cell-cell communication. Interactions with CACNB2, DST, MIA, and NCKIPSD indicate its involvement in diverse cellular pathways, emphasizing its versatile functions in essential activities. TMIGD2 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of TMIGD2 Protein, Human (HEK293, Fc) is 150 a.a., with molecular weight of ~40.9 KDa.

HY-P700704

	*DKK-1 C terminal Domain* Protein, Human (HEK293, Fc-Avi)** Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 C terminal Domain protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 C terminal Domain Protein, Human (HEK293, Fc-Avi) is 89 a.a., with molecular weight of 45-55 kDa.

HY-P700705

	*DKK-1 N terminal Domain* Protein, Human (HEK293, Fc-Avi)** Dickkopf-related 1; Dickkopf-1; Dkk-1; Dkk1; hDkk-1; hDkk1; SK	Human	HEK293
	DKK-1 Proteinas, a potent antagonist of canonical Wnt signaling, inhibits LRP5/6-Wnt interaction and forms a ternary complex with KREMEN, facilitating LRP5/6 internalization. Beyond antagonizing KREMEN1's pro-apoptotic function independently of Wnt, DKK-1 exhibits anti-apoptotic activity. Implicated in limb development, it modulates Wnt signaling for normal limb patterning. Interacting with LRP5/6 through its C-terminal Cys-rich domain, DKK-1 attenuates Wnt-mediated signaling influenced by MESD and/or KREMEN, emphasizing its multifaceted role in regulating cellular processes. DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived DKK-1 N terminal Domain protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. The total length of DKK-1 N terminal Domain Protein, Human (HEK293, Fc-Avi) is 111 a.a., with molecular weight of 50-60 kDa.

HY-P7640

	B7-H4 Protein, Human (HEK293, Fc) rHuB7-H4, C-Fc; B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain-containing T-cell activation inhibitor 1	Human	HEK293
	B7-H4 Protein, Human (HEK293, Fc) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells.

HY-P7643

	B7-H4 Protein, Rhesus macaque (HEK293, Fc) rRhB7-H4, C-Fc; B7-H4; Protein B7S1; T cell costimulatory molecule B7x; V-set domain-containing T-cell activation inhibitor 1	Rhesus Macaque	HEK293
	B7-H4 Protein, Rhesus macaque (HEK293, Fc) may participate in negative regulation of cell-mediated immunity in peripheral tissues. Cell-associated B7-H4 could also inhibit T cell response. B7-H4 acts as a morphogenic factor for cancer cells.

HY-P70665

	Irisin Protein, Human/Mouse/Rat (HEK293, Fc) 1 Publications Verification Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FNDC5	Human	HEK293
	Although the effects of the irisin protein were observed in mice, it may not have a significant role in beneficial outcomes related to muscle building or stimulating browning of white adipose tissue in humans. While previous studies in mice have implicated irisin in these processes, recent studies in humans have cast doubt on its relevance. Irisin Protein, Human/Mouse/Rat (HEK293, Fc) is the recombinant human-derived Irisin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Irisin Protein, Human/Mouse/Rat (HEK293, Fc) is 112 a.a., with molecular weight of 45-60 kDa.

HY-P74201

	Dectin-2/CLEC6A Protein, Human (HEK293, Fc) C-type lectin domain family 6 member A; Dectin-2; Clec6a; Clec4n; Clecsf10	Human	HEK293
	Dectin-2, also known as CLEC6A, functions as a calcium-dependent lectin and pattern recognition receptor (PRR) within the innate immune system, exhibiting specific recognition and binding to alpha-mannans on C. albicans hyphae. Upon binding of C. albicans alpha-mannans, this receptor complex initiates the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, thereby activating SYK, CARD9, and NF-kappa-B. This cascade of events drives the maturation of antigen-presenting cells and influences antigen-specific priming of T-cells, favoring the development of effector T-helper 1 and T-helper 17 cell subtypes. In addition to its role in antifungal defense, Dectin-2 recognizes allergens from house dust mites and fungi in a mannose-dependent manner, promoting cysteinyl leukotriene production. Moreover, it plays a role in altering adaptive immune responses by recognizing soluble elements from the eggs of Schistosoma mansoni. Associated with FCER1G, Dectin-2 forms a heterodimer with CLEC4D, establishing a pattern recognition receptor against fungal infections. The multifaceted functions of Dectin-2 underscore its importance in immune surveillance and response mechanisms. Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is the recombinant human-derived Dectin-2/CLEC6A protein, expressed by HEK293 , with N-hFc labeled tag. The total length of Dectin-2/CLEC6A Protein, Human (HEK293, Fc) is 168 a.a., with molecular weight of ~52 kDa.

HY-P75676

	CLEC10A/CD301 Protein, Human (HEK293, Fc) C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML	Human	HEK293
	CLEC10A/CD301 Protein, implicated in probable immune response regulation, binds Tn-Ag sugar moieties in a calcium-dependent manner. Recognizing these structures on carcinoma cells, CLEC10A/CD301 suggests a role in immune surveillance. Further exploration of its molecular interactions and downstream signaling pathways will enhance understanding of its contributions to immune modulation, especially in the context of cancer immunity. CLEC10A/CD301 Protein, Human (HEK293, Fc) is the recombinant human-derived CLEC10A/CD301 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC10A/CD301 Protein, Human (HEK293, Fc) is 232 a.a., with molecular weight of ~58 kDa.

HY-P75677

	CLEC4F/CLECSF13 Protein, Mouse (HEK293, Fc) C-type lectin domain family 4 member F; C-type lectin 13; Kupffer cell receptor; Kclr	Mouse	HEK293
	CLEC4F/CLECSF13 protein, a receptor with a distinct affinity for galactose and fucose, suggests involvement in endocytosis. With a binding preference for these carbohydrates, it plays a role in recognizing and potentially internalizing cellular components. CLEC4F/CLECSF13's implication in endocytosis highlights its significance in cellular uptake mechanisms, hinting at potential contributions to various physiological processes. CLEC4F/CLECSF13 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC4F/CLECSF13 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC4F/CLECSF13 Protein, Mouse (HEK293, Fc) is 479 a.a., with molecular weight of ~82.1 kDa.

HY-P76265

	CLEC10A/CD301 Protein, Mouse (HEK293, Fc) C-type lectin domain family 10 member A; CD301; CLEC10A; CLECSF13; CLECSF14; HML	Mouse	HEK293
	CLEC10A/CD301 has predicted carbohydrate-binding activity and plays an upstream role in connective tissue replacement in inflammatory responses and wound healing. This protein is expected to be located on the membrane and be an integral part of the membrane structure, being active on the outside of the plasma membrane. CLEC10A/CD301 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CLEC10A/CD301 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of CLEC10A/CD301 Protein, Mouse (HEK293, Fc) is 248 a.a., with molecular weight of ~58 KDa.

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